The research teams

Cutting-edge laboratories within SysChem with a regular track record of recognition

research teams
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researchers
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Nobel Prize in Chemistry
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ERC grants
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(parmi les financements européens les plus prestigieux)

CNRS medals
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From the Nobel Prize winners to the new generation of researchers

Dr Jean-François Lutz

2 ERC

CNRS silver medal (2018)

Dr Giulio Ragazzon

1 ERC

Ranked in the top 5 of the worldwide competition 'Dream Chemistry Award’ in 2021, which rewards young chemists dreaming of solving fundamental problems with bold ideas.

Dr Andrey Klymchenko

2 ERC

CNRS Bronze Medal (2010)

Discover the list of laboratories by research topic

Paolo Samori – Nanochemistry

Alberto Bianco – Therapeutic Multifunctional Carbon and 2D Nanomaterials

Giulio Ragazzon – Driven Chemical Processes

Amir HoveydaCatalytic Chemical Synthesis

Marco Cecchini – Molecular Function and Design

Vincent Robert – Quantum Chemistry

Burkhard BechingerMembrane Biophysics
and NMR

Alberto Bianco – Therapeutic Multifunctional Carbon and 2D Nanomaterials

Peter Faller – Biometals and chemical biology

Petra HellwigBioelectrochemistry
and Spectroscopy

Andrey Klymchenko – Nanochemistry and Bioimaging

Vladimir Torbeev – BioSystems Chemistry

 

Nicolas Giuseppone Self-Assembled Molecular Systems

Jean-Marie LehnSupramolecular Chemistry

Jean-Pierre SauvageOrgano-Mineral Chemistry

Jean-François LutzPrecision Macromolecular Chemistry

Jean-François Nierengarten – Chemistry of Molecular Materials

Membrane Biophysics and NMR

The laboratory studies complex chemical systems as they are present in nature through physicochemical approaches. The team is interested in the structure, dynamics and interaction of membrane-associated peptides and lipids in order to understand their biological function, for example peptides with antimicrobial action. The team also works on the transfection of nucleic acids for gene therapy and personalised medicine. A particular focus relates to auxiliary molecules that make it possible to transport DNA and RNA into cells. The peptides developed at the laboratory exhibit potent transport activities and could be used for the delivery of therapeutic molecules.

Burkhard Bechinger ​

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Therapeutic Multifunctional Carbon and 2D Nanomaterials.

The group led by Alberto Bianco specialises in nanobiotechnologies and nanomedicine. Its different research areas relate to the design, synthesis, characterisation and study of the biomedical applications of carbon-based nanomaterials such as nanotubes, graphene, adamantane or graphene oxide. The team focuses on the development of new strategies for the vectorisation of therapeutic molecules and the design of new imaging tools. This approach has made it possible to develop new vectorisation methods for different classes of biomolecules, such as bioactive peptides, antibiotic and anticancer molecules, DNA or siRNA. The laboratory also covers the fundamental study of the metabolism of carbon nanomaterials, their toxicity, the mechanisms by which they are eliminated from the organism and the way they biodegrade, in order to evaluate their impact on health and validate their use as new therapeutic carriers. The team also explores new approaches involving other two-dimensional materials such as boron nitride (hBN) and transition metal dichalcogenides (e.g. MoS2).

Molecular Function and Design

The laboratory specialises in modelling research, at the interface between life sciences and materials sciences. The team looks at issues of medical and/or technological relevance to develop computational strategies based on cutting-edge molecular simulations and to supply a quantitative interpretation of the fundamental phenomena at the molecular level, from recognition and self-assembly to the allosteric regulation of important neurotransmitter receptors.

Marco Cecchini

Biometals and chemical biology

The group works at the interface of chemistry with biology and medicine. The aims are on the one hand to understand chemical processes in biology and medicine by obtaining mechanistic molecular insights, and on the other hand to synthesize new compounds as chemical tools for biology and/or for potential therapeutic applications. The expertise of the group lies mainly in the chemistry of metal ions, metal-ligand complexes and metal-peptides, in the synthesis of peptides, self-assembly of peptides like amyloids, and bioconjugation.

Application are diverse and include: elaboration of sensors (fluorescence, luminescence, MRI contrast agent, NMR, ..), anticancer and antimicrobial compounds, potential therapeutic compound for neurodegenerative diseases, such as Alzheimer’s or Parkinson disease, biocatalysis by biomaterials.

Peter Faller

Self-Assembled Molecular Systems

The development of stimulable, adaptive and multi-task chemical systems constitutes a major objective to unlock the new generation of so-called “smart” functional materials.

The team is interested in the understanding and control of the processes of self-assembly and self-organisation programmed on the molecular level, and in their dynamics and cooperative effects up to macroscopic scales. This expertise enables them to generate complex systems capable of interacting with their environment and adapting to it through emergence processes. In terms of applications, such properties will be necessary in order to realise this next generation of so-called “smart” materials.

Thanks to their unique combination of expertise ranging from the synthesis of complex molecules to the understanding of the dynamics of self-assembly and the physicochemistry and physics of polymers, the team’s achievements have included the development of self-healable and recyclable materials based on double-dynamic elastomers, with airtightness properties that are being tested on an industrial scale for construction.

Nicolas Giuseppone

Giuseppone3

Bioelectrochemistry and Spectroscopy

The laboratory specialises in the study of enzymes: the extremely effective catalysts present in nature that perform the chemical reactions necessary for cellular life. The catalytic power of enzymes is responsible for the production of substances and energy, which are indispensable for the proper functioning of living organisms.
More specifically, the team uses Raman and infrared (IR) difference spectroscopy, associated with electrochemistry, to study the catalytic function of proteins and to elucidate their mechanisms.

The team’s scientific expertise is based on the use of nanomaterials to engineer direct electrochemical manipulation of membrane proteins. It also develops approaches relating to the thermostability of proteins and the identification of spectroscopic markers of conditions such as Alzheimer’s disease in biological tissues.

Petra Hellwig

Hellwig

Catalytic Chemical Synthesis

Amir Hoveyda was one of the 12 researchers selected in the third-wave call for proposals for the “Make our planet great again” (MOPGA) initiative launched by French President Emmanuel Macron. The research undertaken within the group focuses on stereochemically defined organic molecules, either small molecules or macromolecules, that play or could play a crucial role in drug development and progress in human medicine. In particular, the laboratory works on new methods of catalysis, devoted to the production of high-added-value organic molecules for medicine, such as compounds active against cancers, tumours or hepatitis C.

The objective is to introduce catalytic methods to generate these molecules that are effective, selective, widely applicable and practical (scalable), as well as being sustainable and profitable (for example, no precious metals). The team’s main objective is to develop catalysers, strategies and methods that respond practically and realistically to our major environmental challenges.

Based on the same principles, Amir Hoveyda co-founded XiMo, a European company, alongside Richard Schrock, winner of the Nobel Prize for Chemistry in 2005.

Amir Hoveyda

Hoveyda

Nanochemistry and Bioimaging

The laboratory’s research revolves around the development of new functional molecules and nanoparticles, known as fluorescent probes, for biological and biomedical applications. Thanks to these fluorescent molecular probes, it is possible to achieve imaging of the structure and function of living cells on a molecular level, thanks to new concepts based on different photochemical phenomena. The goal is to exploit these concepts for biodetection and bioimaging, in particular through probes for biomembranes, intracellular organelles, membrane proteins and nucleic acids. Six membrane probes have already been brought to market (by ThermoFisher Scientific and Cytoskeloton).

The team also develops ultrabright self-assembled fluorescent organic nanoparticles, based on polymers or lipids loaded with fluorescent dyes, for biodetection and bioimaging. In particular, based on an innovative design of polymers and ionic dyes with bulky counterions, the laboratory develops nanoparticles of small, controlled size, offering bright fluorescence and efficient energy transfer. These nanoparticles are used as scaffolds for the synthesis of ultrabright nanoprobes for the detection of nucleic acids and proteins in cells and biological liquids. These nanoprobes are relevant both to fundamental research on bioimaging of rare targets and for the ultrasensitive detection of bimolecular markers in diagnostics.
Recently, the team developed new fluorescent materials functioning in the visible and near-infrared regions, which have found applications in image-guided surgery in collaboration with surgeons from the IRCAD research institute.

Andrey Klymchenko

Andrey Klymchenko

Supramolecular Chemistry

The winner of the Nobel Prize for Chemistry in 1987, Jean-Marie Lehn is the founder of supramolecular chemistry. He began his career initially focussing on molecular recognition, and in particular its major role in biological processes. From there, his research broadened out to incorporate catalysis and supramolecular transport processes. It also extended to the design of molecular components as the bases for molecular electronics and photonics.

Another area of development relates to the design of “programmed” systems capable of self-organisation through the spontaneous assemblage of appropriate components into well-defined supramolecular architectures.
The author of over 1,000 publications, he belongs to multiple academies and institutions as well as the boards of private companies.

Jean-Marie Lehn

Jean-Marie Lehn

Precision Macromolecular Chemistry

The team studies the synthesis of so-called “precision” non-natural polymers: very high added value materials with complex arrangements of monomers in their chains. The team focuses on new approaches that must be simple, low-cost and easy to implement.

The team was the first in the world to synthesise “coded” polymers with perfectly controlled sequences of monomers. Like natural macromolecules (proteins, DNA), the laboratory can prepare structures that are perfectly defined at the molecular level. These new materials unlock new applications for polymer materials, for example in anti-counterfeiting.

In addition, with their perfectly controlled structures, these new-generation materials also open the door to polymer data storage. The researchers have been able to write binary code identical to the code used in computing language into polymers: a chemical alternative for information storage in materials that are becoming ever more compact and durable.
Other applications are studied in the laboratory, such as drug delivery via bio-hybrid structures combining synthetic segments with natural macromolecules (DNA aptamers), or the recycling of plastic materials.

 
 
 

Jean-François Lutz

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Chemistry of Molecular Materials

The team is recognised for its contributions in the field of fullerene chemistry, transition metals chemistry and supramolecular chemistry. The research is strongly focused on synthesis and relates to a wide variety of research subjects ranging from the development of molecular materials and bioactive compounds to the construction of supramolecular assemblages with novel electronic properties.
More recently, the team launched a new research program relating to the chemistry of pillar[5]arenes, unique macrocyclic compounds with therapeutic applications that have yet to be explored.

Jean-François Nierengarten

Nierengarten2

Driven Chemical Processes

The research of this group is inspired by how energy conversion happens in biology. Learning from nature, this group studies fully artificial molecules capable of absorbing energy from a source. In other words, unconventional strategies for energy conversion.

Examples of energy sources are light, electricity, and chemical energy. We might be less used to considering chemical energy among the three mentioned, but that’s what powers our biology, and chemists are learning only now to engineer mechanisms that harvest chemical energy to perform useful tasks. By learning how to absorb energy, we can realize processes that are impossible without an energy source, such as assembling high-energy structures, transporting molecules in specific compartments, and even cooling the surroundings – in the same way a fridge requires electricity to work.

The core expertise of this laboratory is experimental measurements using techniques that unravel molecular properties, mostly in solution. Yet, the laboratory spans from synthetic organic chemistry to theoretical investigations, with an outlook on material science and biochemical processes. A concrete long-term motivation for this research is to tackle mitochondrial diseases, which affect the organelles that generate energy for the cell. These diseases remain without a cure, possibly because we have not yet unraveled energy conversion phenomena at the molecular level.

Giulio Ragazzon

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Quantum Chemistry

The activity undertaken at the laboratory relates to the use of theoretical tools and their development to describe the electronic properties of molecular architectures and materials. The complexity emerges from the nature of the inter- and intra-molecular interactions governed by electronic correlation, weak bonds or charge transfers. By examining these phenomena, it is possible to account for remarkable behaviours such as molecular magnetism, spin transition, spintronics and molecular recognition.

Vincent Robert

Robert

Nanochemistry

The laboratory’s research activity revolves around the relationship between architecture and function in organic or graphene-derived multifunctional nano-structured materials. This research work is based on a combination of approaches involving supramolecular chemistry, hierarchical self-assembly, the nanochemistry/nanophysics of surfaces and interfaces, the development of functional materials and the study of their fundamental physicochemical properties, as well as the production of optoelectronic (nano)devices based on hybrid supramolecular architectures.

The team is interested in the chemistry of bidimensional (2D) materials, smart supramolecular systems and high-performance multifunctional materials and (nano)devices in order to develop an “internet of functions” for energy, detection and optoelectronic applications. This includes: Engineering of 2D materials (graphene and other layered compounds): production, regulation of their properties, production of devices for optoelectronics and detection;
Multi-scale adaptation of smart supramolecular systems: development of multi-reactive hybrid materials; High-performance multifunctional materials and (nano)devices for optoelectronics, detection, data storage, energy storage, etc.

Paolo Samori

samori2

Organo-Mineral Chemistry

Jean-Pierre Sauvage was awarded the Nobel Prize for Chemistry in 2016. This distinction rewarded his pioneering work on the design and synthesis of molecular machines. These nanometric-scale assemblages are capable of controlled motion in response to various signals, such as UV light, for example.

Nature abounds with complex protein machines that chemists are trying to decipher. Like a muscle that contracts, they play a part in numerous biological processes. Inspired by these processes, Jean-Pierre Sauvage devoted his career to synthesising molecules that behave like machines. The challenge lies in being able to trigger and control their movement using signals (physical, chemical, electrical, etc.) that alter the balance of forces between their atoms. Oscillating rotary systems, molecular “shuttles” and artificial muscles on a nanometric scale are some of the synthetic dynamic systems he has developed.

These nanomachines are destined for a bright future. Numerous applications are currently being studied: targeted transport of pharmaceuticals, design of deformable materials, information storage in “molecular” computers, light-controlled molecular switches…

Jean-Pierre Sauvage

Sauvage

BioSystems Chemistry

This research group specialises in the chemistry, biology and characterisation of proteins using biophysical tools, in order to study biological problems, particularly relating to neurodegenerative diseases. Research topics include the molecular foundations of protein misfolding, methodologies for high-throughput combinational protein synthesis, new chemistry-based approaches to study and target intrinsically disordered proteins and protein design. The team is developing new tools that will enable the robust chemical synthesis of protein libraries comprising 100-10,000 compounds.

Vladimir Torbeev

VTorbeev